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The nearest rail access is via the OKC Streetcar, a light rail service. The Scissortail Park stop on the Downtown Loop is a 2-minute walk west along West Reno Avenue, directly adjacent to the arena.

Numerous EMBARK bus routes serve the downtown area. Key stops are located along West Reno Avenue and South Robinson Avenue, offering connections across Oklahoma City. The Greyhound bus terminal is a 10-minute walk south-east from the arena.

Multiple parking options are available within a 10-minute radius. The Prairie Surf Studios Garage (formerly Cox Convention Center Garage) is a 3-minute walk north across West Reno Avenue. Other nearby paid garages include the Santa Fe Garage and numerous surface lots. Advance booking is strongly advised for major events due to high demand and dynamic pricing.

The O2 Arena is committed to providing an accessible experience for all its visitors. The venue is largely wheelchair accessible, with accessible entrances, lifts to all public areas, and dedicated wheelchair viewing spaces in the arena bowl. Accessible toilet facilities are available throughout the venue, and all are clearly signposted. Hearing assistance is provided via an induction loop system within the arena; visitors should check with venue staff upon arrival for specific locations. Assistance dogs are welcome, and facilities for service animals are available. Accessible parking is located within the main car park, and staff are trained to offer assistance to visitors with disabilities, ensuring a smooth and enjoyable visit. Visitors are encouraged to contact the venue's accessibility team in advance to discuss specific requirements.

Main entrances are situated along West Reno Avenue and South Robinson Avenue. Queue arrangements vary by event, but all patrons should anticipate standard security screening, including metal detectors and bag checks. To ensure smooth entry and avoid missing initial proceedings, arriving at least 45 minutes prior to the advertised start time is recommended.